中文摘要：

真核翻译延伸因子1A1（eukaryotic translation elongation factor 1A1，eEF1A1）是一个在蛋白质合成过程中发挥肽链延伸作用的重要因子，在细胞生长过程中起着重要作用。研究表明，eEF1A1的作用不只局限于肽链的延伸过程，还可参与蛋白质翻译后修饰、蛋白质降解以及细胞骨架的调节等生理活动，这些非经典功能使其在细胞增殖、凋亡以及肿瘤细胞侵袭和转移等方面均发挥了重要作用，干扰eEF1A1的表达可以影响肿瘤化疗的敏感性，eEF1A1可能成为一个潜在的肿瘤防治靶点。本文对近年来关于eEF1A1在肿瘤发生和发展中作用的研究进展进行简要综述。

英文摘要：

Eukaryotic translation elongation factor 1A1 （eEF1A1） is an important factor in polypeptide chain elongation and plays an important role in cell growth. The function of eEF1A1 is not only limited in polypeptide chain elongation but also participates in protein post-translational modification, protein degradation, regulation of cytoskeleton and other physiological activities. Through these non-canonical functions, eEF1A1 plays an important role in proliferation, apoptosis, invasion and metastasis of tumor cells. Moreover, knockdown of eEF1A1 can enhance the chemosensitivity of tumor cells. These results indicate that eEF1A1 may become a potential target for prevention and treatment of cancer. This article reviews the latest advances in potential role of eEF1A1 in tumorigenesis and progression.