中文摘要：

中枢神经系统虽不被免疫系统监视，但阿尔茨海默病（AD）患者的特异性免疫细胞可通过血脑屏障进入大脑，因此AD免疫病理学机制是近年来的关注热点。先天性免疫反应和特异性免疫反应是炎症促进AD发病的两种主要机制。文章主要综述淋巴细胞、神经胶质细胞、补体系统、细胞因子、氧化应激等相关炎症介质与AD脑内免疫激活的相互影响及作用机制。

英文摘要：

The central nervous system is not monitored by the immune system,but the specific immune cells of AD patients can enter the brain through the blood - brain barrier, so AD immunopathologic mechanisms are the focus of attention in recent years. Innate immune response and specific immune response are the two main mechanisms for the inflammation promoting patho- genesis of AD. This paper mainly reviews the interaction and mechanism between the AD immune activation in brain and inflam- matory mediators such as lymphocyte, glial cells, complement system, cytokines and oxidative stress.