中文摘要：

目的：探讨纹状体的功能连接和精神分裂症临床症状的关系。方法：运用基于体素的功能连接分析法来识别精神分裂症患者纹状体与其他脑区功能连接的异常,入组对象为70位精神分裂症患者和60位年龄、性别相匹配的健康对照。结果：与健康对照比较,我们发现患者的左侧尾状核与左侧额中回、左侧额上回以及左侧丘脑,右侧尾状核与右侧额中回、左右两侧丘脑,右侧壳核与右侧楔叶均表现为功能连接减弱。相关分析发现,左侧尾状核和左侧额中回的功能连接强度与患者阳性症状量表的幻觉评分成负相关,右侧尾状核与右侧丘脑的功能连接强度与患者阳性症状量表的怪异行为呈正相关。结论：结果显示精神分裂症患者额叶-纹状体-丘脑环路静息态功能连接存在异常。并且此环路中的左侧尾状核与左侧额中回以及右侧尾状核与右侧丘脑的功能连接异常可能分别为精神分裂症患者幻觉和怪异行为的神经生物学基础。

英文摘要：

Objective： To explore the relationship between the functional connectivity of the striatum and clinical symptoms of schizophrenia. Methods： Voxel-based resting-state functional connectivity analyses were performed to identify the functional connectivity of the striatal regions in whole brain in 70 schizophrenia patients and 60 age- and sex-matched healthy controls. Results： We found the functional connectivity between the left eaudate（CAU） and left middle frontal gyrus （MFG）, left superior frontal gyrus（SFG） and left thalamus（THA）, right CAU and right MFG, left THA and right THA, and right putamen（PUT） and right cuneus（CUN） to be significantly decreased in the schizophrenia patient group compared to the healthy controls. Moreover, the functional connectivity between the left CAU and MFG was found to be negatively associated with hallucinations in patient group. Moreover, a positive correlation was found between bizarre behavior and the functional connectivity of the CAU with THA. Conclusion： These findings demonstrate resting-state functional abnormalities of the frontal-striatal-thalamic（FST） circuit in schizophrenia. Moreover, the significantly altered functional connectivity between the left CAU and left MFG and between the right CAU and right THA in the FST circuit may be the underlying neuro-substrates, respectively, for the hallucinations and bizarre behaviors observed in schizophrenia patients.