中文摘要：

肝纤维化是多种慢性肝病进展至肝硬化的中间过程,其特征是以胶原蛋白为主的细胞外基质（extracellular matrix,ECM）的合成与降解失衡,导致大量ECM沉积。在肝纤维化发生、发展过程中,常伴有肾素–血管紧张素–醛固酮系统（renin-angiontensin-aldosterone system,RAAS）的激活,血管紧张素转换酶–血管紧张素II-血管紧张素II受体1（angiotensin-converting enzymeangiotensin IIangiotensin II type 1 repector,ACE-Ang II-AT1R）轴和血管紧张素转换酶2-血管紧张素（1-7）-Mas受体[angiotensin-converting enzyme 2-angiotensin（1-7）-Mas,ACE2-Ang（1-7）-Mas]轴是调节肝纤维化的两大重要因素。

英文摘要：

Liver fibrosis is the transition of many chronic liver diseases to liver cirrhosis, which is characterized by the imbalance of extracellular matrix（ECM） synthesis and degradation, leading to a large amount of ECM deposition. During the development of liver fibrosis, it＇s often accompanied by the activation of reninangiontensin-aldosterone system（RAAS）. The angiotensin-converting enzymeangiotensin II-angiotensin II type 1 repector（ACE-Ang II-AT1R） and angiotensin-converting enzyme 2-angiotensin（1-7）-Mas [ACE2-Ang（1-7）-Mas] of RAAS are two most important regulating factors for the process of liver fibrosis.