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中文摘要：
目的测定葫芦素E溶解度、正辛醇-水分配系数及脂质体-水分配系数。方法分别采用平衡法、经典摇瓶法及平衡透析法测定葫芦素E溶解度、正辛醇-水分配系数及脂质体-水分配系数。结果葫芦素E在水中溶解度为0.155 mg.L-1,在乙醇、叔丁醇中有潜溶现象;正辛醇-水分配系数为（2.088±0.054）;脂质体-水分配系数为0.003~1.819。结论葫芦素E为水不溶性药物;正辛醇-水分配系数及脂质体-水分配系数均中等偏低。
英文摘要：
Objective To determine the solubility of cucurbitacin E and its partition coefficients for n-octanol-water and liposome-water solution systems.Methods The solubility,partition coefficient for n-octanol-water and liposome-water were measured by equilibrium method,shaking flask and equilibrium dialysis method,respectively.Results The solubility of cucurbitacin E in water was 0.155 mg·L-1,it was cosolvent in ethanol and tertiary butyl alcohol,the partition coefficients for n-octanol-water and liposome-water were（2.088±0.054）and（0.003-1.819）,respectively.Conclusions Cucurbitacin E is insoluble in water,its partition coefficients for n-octanol-water and liposome-water are moderate.
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