中文摘要：

低频超声和真空负压透皮抽取出的组织液体积小且在皮肤表面呈散点状分布，使得对微量组织液进行收集、定量、输送和浓度检测存在很大困难。针对这一问题，基于组织液透皮抽取式微流控芯片和微机械葡萄糖浓度传感器，研制了一套组织液透皮抽取式微创血糖检测仪。设计了该微创血糖仪各部分功能器件及其接口电路，完成了该仪器系统硬件设计和软件设计，并通过搭建的离体猪皮模拟组织液透皮抽取实验系统，验证了组织液透皮抽取式微创血糖检测仪的性能和测量结果的准确性。

英文摘要：

Interstitial fluid （ISF） transdermally extracted using low-frequency ultrasound and continuous vacuum negative pressure feature,; tiny volume and has scattered distribution on skin surface, which makes the transdermal extraction, collection, transport, volumetric detection and glucose concentration measurement of the ISF very difficult. Aiming at this problem, based on micro-fluidic chip for ISF transdermal extraction and micro-mechanical glucose concentration sensor, a minimally invasive blood glucose monitoring detector was developed. Various function parts of the detector and their interface circuits were designed ; the hardware and software designs of the detector were completed. A simulation experiment system of transdermal ISF extraction for full-thickness pig skin was developed ; using this system, pig skin in vitro experiment was performed, which verifies the performance and measurement accuracy of the developed detector.