中文摘要：

角结膜干燥症（干眼）是眼科常见病，严重影响患者的生活质量。对于重症患者，传统治疗方法效果不佳。1999年以来，北京大学口腔医院与北京同仁医院眼科合作，采用血管化自体颌下腺移植治疗重症角结膜干燥症105例（108侧）。其中95侧（88％）移植腺体成活，导管通畅，手术治疗成功。患者畏光怕风症状缓解，眼干症状消失或明显减轻，可停用人工泪液，泪膜破裂时间延长，角膜荧光着色减少，部分患者视力有不同程度提高。血管化自体颌下腺移植已成为目前治疗重症角结膜干燥症行之有效的方法。

英文摘要：

SUMMARY In order to investigate the secretion mechanism of denervated submandibular gland（SMG） and artificially regulate the secretion of transferred SMG, serial studies on the secretion function of normal and transferred SMG have been performed. The results showed that （AR） were expressed in human SMG, and might contribute to the functional α1A and α1B.adrenoceptors regulation of saliva synthesis and secretion. Both β,- and β2-AR were expressed in rabbit SMG. β1-AR was the predominant subtype and might play an important role in regulating saliva and a-amylase secretion. Vanilloid receptorl （VR1） mRNA and protein were detected in rabbit SMG. Capsaicin could induce a significant increase in secretion of rabbit SMG via activitation of VR1. On the rabbit model of microvascular transfer of SMG, phenylephrine（ 10^-7 mol/L）was infused into SMG through the Wharton＇ s duct. The secretion of transferred SMG was significantly increased without significant changes of cardiovascular function. The effective mechanism of phenylephrine might involve the increased expression of α1-AR, translocation of AQP5 from cytoplasm to apical membrane, activation of signal molecules related to cell proliferation, and moderate the atrophy of the gland. These results provided a experimental basis for deeply understanding of secretion mechanism of normal and transferred SMG, and effective regulation of secretion of the transferred SMG.