中文摘要：

目的探讨双重膜过滤血浆置换（DFPP）治疗多发性骨髓瘤（MM）伴高球蛋白血症的临床疗效。方法对22例MM伴高球蛋白血症患者采用DFPP治疗，治疗前后检测其血清白蛋白、球蛋白、M蛋白、血沉（ESR）、血红蛋白（Hb）、纤维蛋白原（Fib）、D-二聚体（D—D）及β2-微球蛋白（β2-M）变化，记录治疗相关不良反应。结果与置换前比较，置换后患者血清球蛋白、M蛋白、ESR明显下降（P均〈0．05）；而Fib、β2-M及D—D下降及白蛋白升高不明显（P均〉0．05），Hb无明显变化；均未出现严重过敏、血小板减少、低钙血症、出血等不良反应。结论DFPP治疗短期内MM伴高球蛋白血症患者的多种生化指标明显改善，可为MM的有效治疗赢得时间。

英文摘要：

Objective To discuss the clinical effectiveness of double filtration plasmapheresis （DFPP） in muhiple myeloma with hyperglobulinemia. Methods DFPP was used to treat the 22 cases of multiple myeloma （MM） patients with hyperglobulinemia. The levels of albumin, globulin, monoclonal immunoglobulin （M protein） , erythrocyte sedimentation rate （ ESR）, haemoglobin （ Hb）, fibrinogen （ Fib）, and D-Dimer （D-D） in MM patients with hyperglobulinemia were de- tected before and after treatment, and related adverse reactions were recorded. Results The levels of globulin, monoclonal immunoglobulin, and ESR had been decreased significantly after treatment （ all P 〈 0.05）. Fib and D-D value were lower, and the level of albumin was higher after treatment, but the difference was no significant difference （ all P 〉 O. 05 ）. No change had happened on the level of haemoglobin. And no serious anaphylactic reaction, thrombocytopenia, hypocalcemia, bleeding or other adverse reactions occurred during the period. Conclusion DFPP improves the biochemical data in multi- ple myeloma patients with hyperglobulinemia in a short time significantly, and won more time for the effective clinical treat- ment of multiple myeloma.