中文摘要：

目的通过对正常志愿者脑深部小静脉磁敏感加权成像（SWI）相位值（Δφ）的测量,评价健康人群脑静脉血氧含量的年龄、性别、侧别差异,探讨颅内小静脉血氧含量与深部灰质核团铁沉积的相关性。资料与方法 56例健康志愿者行SWI扫描,应用神经影像信号处理软件生成滤过后的相位图,比较双侧基底静脉（BV）、大脑中深静脉（DMCV）、大脑内静脉（ICV）、丘纹上静脉（STV）Δφ,比较健康志愿者男性与女性、左侧与右侧各静脉Δφ。测量双侧尾状核头、苍白球、壳核、丘脑、黑质和红核Δφ,分析健康志愿者脑静脉Δφ值与年龄、深部核团相位值的相关性。结果脑深部静脉中,DMCVΔφ明显低于BV、ICV、STV（P〈0.05）,ICVΔφ高于其他静脉（P〈0.05）,BVΔφ与STV比较差异无统计学意义（P〉0.05）。男性与女性、左侧与右侧的BV、DMCV、ICV、STVΔφ比较,差异均无统计学意义（P〉0.05）。BV、DMCV、ICVΔφ与年龄无相关性（P〉0.05）。BV、DMCV、STVΔφ与双侧尾状核头、双侧苍白球、双侧壳核、左侧红核呈正相关（P〈0.05）,BV与左侧丘脑Δφ呈正相关（P〈0.05）,ICV与双侧壳核Δφ呈正相关（P〈0.05）,DMCV、STV与右侧红核Δφ呈正相关（P〈0.05）,DMCV、ICV、STV与左侧黑质Δφ呈负相关（P〈0.05）。结论正常人脑静脉Δφ值存在部位差异,无年龄、性别及侧别差异;脑深部核团铁沉积与脑静脉血氧含量存在相关性。

英文摘要：

Purpose To assess brain venous phase values（Δφ） change with age, gender, and location using susceptibility weighted imaging（SWI）, and to explore the correlation between iron depositions in nuclei and venous oxygen concentration in healthy volunteers. Materials and Methods Fifty-six healthy volunteers underwent SWI examinations. Filtered phase imaging were acquired with signal process in neuroimaging, and the Δφwere measured in bilateral basal vein（BV）, deep middle cerebral vein（DMCV）, internal cerebral vein（ICV）, superior thalamostriate vein（STV）, respectively, and compared the Δφ values between the female and male volunteers, and between left and right sides. In addition, the phase value of bilateral heads of caudate nucleus（HCN）, globuspallidus（GP）, putamen（PUT）, thalamus（THA）, substantianigra（SN）, red nucleus（RN） were measured in all subjects, and analyzed the correlation between the Δφ of brain veins and deep gray nucleis. Results In healthy volunteers, the Δφ of DMCV was lower than that of BV, ICV and STV（P〈0.05）; the Δφ of ICV was higher than that of the other veins（P〈0.05）. There were no significant differences in the Δφ between BV and STV（P〈0.05）. There were no significant differences in the Δφ between male and female or right and lift（P〈0.05）. No correlation of BV, DMCV, ICV and age in the Δφ（P〈0.05）. The positive phase correlations were found between veins（BV, DMCV and STV） and deep gray nuclei（HCN, PUT and GP）（P〈0.05）. Conclusion The Δφ in cerebral veins which reflects the blood oxygen content is not age-dependent without gender or side differences in healthy people. The Δφ of cerebral veins is related with the phase of the deep brain nuclei which reflects iron deposition.