中文摘要：

目的研究扶正化瘀胶囊对心肌梗死大鼠心肌缝隙连接蛋白43（connexin 43，CX43）表达的影响。方法SD雄性大鼠随机分为假手术组、模型组以及扶正化瘀胶囊组和卡托普利组，每组各6只，采用结扎左冠状动脉前降支造成心肌梗死。术后10d开始灌胃给药，持续8周。用免疫组织化学方法观察心肌CX43表达的变化。结果在心肌梗死区域内，模型组与假手术组比较．CX43排列紊乱，阳性表达面积、平均光密度值和积分光密度均显著低于假手术组（P〈0．01）。在梗死边缘区，扶正化瘀胶囊组CX43平均光密度值高于模型组（P〈0．01），积分光密度高于模型组（P〈0．05），CX43排列紊乱有所减轻，阳性表达面积与模型组无统计学意义。卡托普利组CX43平均光密度值高于模型组（P〈0．01），积分光密度和阳性表达面积均高于模型组（P〈0．05），CX43排列紊乱也有减轻。结论扶正化瘀胶囊能够部分改善心肌梗死大鼠心肌的CX43重构。

英文摘要：

Objective To study the effect of Fuzhenguuayu Capsule on the expression of connexin 43 in rats after myocardial infarction. Methods The myocardial infarction was induced by ligation of the left coronary artery. Rats were randomly divided into the sham- operative group, model group, Fuzhenghuayu group and captopril group. Ten days after operation, the rats were treated for 8 weeks. The expression of Cx43 in heart tissue was determined by immunohistochemistry. Results Compared with sham group, the disordered arrange of CX43, the area of positive expression, the average optical and the optical of accumulated points were significantly lower（ P〈 0.01 ）in model group. Compared with model group, the average optical and the optical of accumulated points were obviously increased in Fuzhenghuayu group. The area of positive expression has no significant deviation. Compared with model group, the area of positive expression, the average optical and the optical of accumulated points were significantly increased in the Captopril group. Conclusion Fuzhenghuayu Capsule could partly improve the reeonstitution of CX43 in heart tissue of rat after myocardial infarction.