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Bioactivity and constituents of several common seaweeds
  • ISSN号:1673-9078
  • 期刊名称:《现代食品科技》
  • 时间:0
  • 分类:S816.7[农业科学—饲料科学;农业科学—畜牧学;农业科学—畜牧兽医] Q949.254[生物学—植物学]
  • 作者机构:[1]School of Environmental and Chemical Engineering,Dalian Jiaotong University, [2]School of Life Science and Biotechnology,Dalian University of Technology
  • 相关基金:supported by the National Natural Science Foundation of China (20902009); Postdoctoral Science Foundation of China (2011M-500051 and 2012T50242); the Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences (kf201009); the Scientific and Technological Fund of Dalian (2008J23JH041)
中文摘要:

从北黄海的 Dalian intertidal 地区的 8 棵普通海草的 Bioactivity 和成分被调查。在 anti-methicillin-resistant 葡萄球菌 aureus (MRSA ) ,测试, Symphyocladia latiuscula 和 Enteromorpha intestinalis 与比 1.0 mg mL1 低得多的 MIC 显示出明显的活动。在 DNA 损坏修理测试(DDRT ) , Chondrus ocellatu 对 DNA 修理有缺陷者 E 显示出选择禁止的活动。coli 紧张对野类型的 E。coli 紧张;当时 Sym。latiuscula, Enteromorpha intestinalis 和 Sar。kjellmanianum 显示出重要 anti-E。有 64128 g mL1 的 MIC 的 coli 活动。在 anti-Pyricularia oryzae 测试, Sym。latiuscula 和 Rh。confervoides 强烈禁止了 P 的孢子的萌芽。琼脂板上的 oryzae。在盐水虾 larvicidal 测试, Sym。latiuscula, Rh。confervoides 和 Sar。kjellmanianum 对盐水虾幼虫展出了有势力毒性,与比 1 mg mL1 低得多的 LC50。HPTLC 分析揭示了他们的多样化的第二等的代谢物。最强壮的种类 Sym 的 HPLC-DAD-MS 分析。latiuscula 并且数据库寻找证明它能生产相当多样化的代谢物,包括 halogenated,其中一些可以是新自然产品。结果在新抗菌素, antitumor 药,农业杀真菌剂和杀虫剂的发展表明了这些海草的潜力。

英文摘要:

Bioactivity and constituents of 8 common seaweeds from Dalian intertidal zone of northern Yellow Sea were investigated. In the anti-methicillin-resistant Staphylococcus aureus (MRSA) test, Symphyocladia latiuscula and Enteromorpha intestinalis showed obvious activities with MICs much lower than 1.0 mg·mL-1 . In the DNA damage repair test (DDRT), Chondrus ocellatu showed selective inhibitory activity against the DNA repair-defective E. coli strain vs. the wild-type E. coli strain; while Sym. latiuscula, Enteromorpha intestinalis and Sar. kjellmanianum showed significant anti-E. coli activity with MICs of 64-128 g·mL-1 . In the anti-Pyricularia oryzae test, Sym. latiuscula and Rh. confervoides strongly inhibited the germination of the spores of P. oryzae on agar plate. In the brine shrimp larvicidal test, Sym. latiuscula, Rh. confervoides and Sar. kjellmanianum exhibited potent toxicity against brine shrimp larvae, with LC50 much lower than 1 mg·mL-1 . The HPTLC analysis revealed their diversified secondary metabolites. The HPLC-DAD-MS analysis of the strongest species Sym. latiuscula and database searching showed that it can produce quite diversified metabolites, including halogenated ones, some of which may be new natural products. The results demonstrated the potentials of these seaweeds in the development of new antibiotics, antitumor drugs, agricultural fungicides and pesticides.

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期刊信息
  • 《现代食品科技》
  • 北大核心期刊(2011版)
  • 主管单位:华南理工大学
  • 主办单位:华南理工大学
  • 主编:李琳
  • 地址:广州市天河区五山路华南理工大学麟鸿楼号508室
  • 邮编:510640
  • 邮箱:xdspkj@vip.sohu.com
  • 电话:020-87112373
  • 国际标准刊号:ISSN:1673-9078
  • 国内统一刊号:ISSN:44-1620/TS
  • 邮发代号:46-349
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,美国工程索引,中国中国科技核心期刊,中国北大核心期刊(2011版),中国北大核心期刊(2014版),英国食品科技文摘
  • 被引量:20414