从北黄海的 Dalian intertidal 地区的 8 棵普通海草的 Bioactivity 和成分被调查。在 anti-methicillin-resistant 葡萄球菌 aureus (MRSA ) ,测试, Symphyocladia latiuscula 和 Enteromorpha intestinalis 与比 1.0 mg mL1 低得多的 MIC 显示出明显的活动。在 DNA 损坏修理测试(DDRT ) , Chondrus ocellatu 对 DNA 修理有缺陷者 E 显示出选择禁止的活动。coli 紧张对野类型的 E。coli 紧张;当时 Sym。latiuscula, Enteromorpha intestinalis 和 Sar。kjellmanianum 显示出重要 anti-E。有 64128 g mL1 的 MIC 的 coli 活动。在 anti-Pyricularia oryzae 测试, Sym。latiuscula 和 Rh。confervoides 强烈禁止了 P 的孢子的萌芽。琼脂板上的 oryzae。在盐水虾 larvicidal 测试, Sym。latiuscula, Rh。confervoides 和 Sar。kjellmanianum 对盐水虾幼虫展出了有势力毒性,与比 1 mg mL1 低得多的 LC50。HPTLC 分析揭示了他们的多样化的第二等的代谢物。最强壮的种类 Sym 的 HPLC-DAD-MS 分析。latiuscula 并且数据库寻找证明它能生产相当多样化的代谢物,包括 halogenated,其中一些可以是新自然产品。结果在新抗菌素, antitumor 药,农业杀真菌剂和杀虫剂的发展表明了这些海草的潜力。
Bioactivity and constituents of 8 common seaweeds from Dalian intertidal zone of northern Yellow Sea were investigated. In the anti-methicillin-resistant Staphylococcus aureus (MRSA) test, Symphyocladia latiuscula and Enteromorpha intestinalis showed obvious activities with MICs much lower than 1.0 mg·mL-1 . In the DNA damage repair test (DDRT), Chondrus ocellatu showed selective inhibitory activity against the DNA repair-defective E. coli strain vs. the wild-type E. coli strain; while Sym. latiuscula, Enteromorpha intestinalis and Sar. kjellmanianum showed significant anti-E. coli activity with MICs of 64-128 g·mL-1 . In the anti-Pyricularia oryzae test, Sym. latiuscula and Rh. confervoides strongly inhibited the germination of the spores of P. oryzae on agar plate. In the brine shrimp larvicidal test, Sym. latiuscula, Rh. confervoides and Sar. kjellmanianum exhibited potent toxicity against brine shrimp larvae, with LC50 much lower than 1 mg·mL-1 . The HPTLC analysis revealed their diversified secondary metabolites. The HPLC-DAD-MS analysis of the strongest species Sym. latiuscula and database searching showed that it can produce quite diversified metabolites, including halogenated ones, some of which may be new natural products. The results demonstrated the potentials of these seaweeds in the development of new antibiotics, antitumor drugs, agricultural fungicides and pesticides.