中文摘要：

为分析2型糖尿病患者神经-内分泌-免疫网络紊乱情况及其临床意义，选择174例经临床诊断明确的2型糖尿病患者。用放射免疫法和流式细胞技术检测外周血中CD4^＋、CD8^＋、NK细胞数量、CD4^＋／CD8^＋比值及IL-1β、IL-6、TNF—α、ACTH、CORT、DA、NE水平，选择30例健康志愿者为正常对照组进行相同检测。结果显示，与正常对照相比，2型糖尿病患者CD4^＋．CD8^＋及NK细胞数量下降（P〈0．01），CD8^＋及CD4^＋／CD8^＋比值升高（P〈0．01），IL-1β、IL-6和TNF—α均有升高（P〈0．01），ACTH及CORT下降（P〈0．01），DA和NE升高（P〈0．01）。研究表明，2型糖尿病患者神经-内分泌-免疫网络的紊乱中，其体液免疫增强、细胞免疫减弱。交感神经兴奋及应激性内分泌功能减弱为主要表现。对于2型糖尿病的治疗。除采用现有手段。应加强机体对胰岛素抵抗调控平衡态的修复与重建，重视神经-内分泌-免疫系统标志的检测及相应的新治疗研究。

英文摘要：

To investigate the disorder of neuro-endocrine-immune network in patients with type-2 diabetes milletus and its clinical significance, 174 patients with clinical proven type-2 diabetes mellitus were enrolled in the study. Radio-immune technology and flow cytometer technology were used to detect the blood levels of CD4^＋, CD8^＋, NK and CD4^＋/CD8^＋, and cytokines including IL-1β, IL-6, TNF- α, ACTH, CORT and DA as well as NE. Analyses were performed on the basis of gender with 33 normal people served as the control group. A significant decrease of CD4^＋, CD8^＋, NK lymphocytes count, and a significant increase of CD4^＋/CD8^＋ were found in type-2 diabetes milletus patients compared with the control group （P〈0.01）. Low IL-1β, IL-6 and TNF-α levels were found in type-2 diabetes milletus groups （P〈0.01）. The serum ACTH, CORT levels were decreased in type-2 diabetes milletus patients （P〈0.01）; both serum DA and NE levels were increased in type-2 diabetes milletus groups compared with the normal group （P〈0.01）. The disturbance of neuroendocrine-immune network in patients with type-2 diabetes milletus is characterized by the humoral immunity activated and cellular immunity depressed; symphathetic nerve activated;the stress related endocrine depressed. It is important to strengthen and recover the balance of neuro-endocrine-immune network, for the treatment of type-2 diabetes mellitus, which is an important issue for the future research on diabetes.