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中文摘要：
以可生物降解的亲水性天然葡聚糖为反应底物，通过缩醛化反应制备两亲性的缩醛化葡聚糖，核磁共振、傅里叶红外等理化表征手段确定缩醛化葡聚糖成功地合成。利用乳化法制备出载药缩醛化葡聚糖纳米粒子，用动态光散射法测得粒径为501．9±15．8nm。且具有优异的pH响应性，荧光分光光度计检测载药纳米粒子在pH=5．0的缓冲介质中阿霉素荧光药物的酸敏释放的荧光强度增强5倍，说明所设计的纳米载药系统具有酸敏释药功能。
英文摘要：
The pH-sensitive acetal-modified dextran was synthesized from dextran with 2-methoxypropene and characterized by using 1H-NMR and IR. And the acetal-modified dextran was used to prepare anticancer drug doxorubicin-loaded nanoparticles by o/w method. The results of dynamic light scattering （DLS） exhibited the size of drug-loaded nanoparticles was 501.9±15.8 nm. DOX release from the pH-sensitive polymeric nanoparticles was qualitatively assessed using fluorescence spectra. The DOX fluorescence intensity of polymeric nanoparticles solution at pH 7.4 was very weak, while it was significantly intensified upon pH 5.0. It showed that the ability of pH-sensitive drug release. Therefore the nanoparticles system has good potential for anticancer drug delivery.
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