中文摘要：

目的：探讨血清MMP-7和MMP-10的检测在卵巢癌诊断中的意义。方法：选取59例卵巢癌患者，52例卵巢良性肿瘤患者和40例健康体检妇女（正常对照组）为研究对象。采用ELISA方法测定血清中MMP-7和MMP-10的水平。结果：恶性组血清MMP-7和MMP-10的水平明显高于良性组和对照组（P〈0．01）。良性组血清MMP-10水平高于对照组（P〈0．01）。血清MMP-7和MMP-10的ROC曲线下面积分别为0．723和0．826。血清MMP-7和MMP-10的联合诊断灵敏度为95．2％，特异度为94．8％。结论：血清MMP-7和MMP-10的检测可以用于卵巢癌的诊断，两者联合诊断可大大提高卵巢癌的检出率。

英文摘要：

Objective： To explore the significance of joint detection of serum matrix metalloproteinase -7 （MMP -7 ） arid matrix metalloproteinase- 10 （MMP- 10） for diagnosis of ovarian cancer. Methods： A total of 59 patients with ovarian cancer, 52 patients with benign ovarian tumor, and 40 healthy women receiving physical examination （ control group） were recruited in this study. ELISA was used to detect the levels of MMP -7 and MMP - 10 in serum. Results： The serum levels of MMP -7 and MMP - 10 in ovarian cancer group were statistically significantly higher than those in benign ovarian tumor group and control group （ P 〈 O. 01 ） . The serum level of MMP - 10 in benign ovarian tumor group was statistically significantly higher than that in control group （P 〈 0. 01 ） . The areas under ROC curve of serum MMP - 7 and MMP - 10 were 0. 723 and 0. 826, respectively. The sensitivity and specificity of joint detection of serum MMP - 7 and MMP - 10 were 95.2% and 94.8%, respectively. Conclusion： Joint detection of serum MMP -7 and MMP - 10 can be used for diagnosis of ovarian cancer, which can significantly increase the detection rate of ovarian cancer.