中文摘要：

背景与目的：宫颈腺鳞癌是宫颈癌的一种病理类型,发病率较低。本研究分析宫颈腺鳞癌的临床病理特点及影响预后的因素,以探讨宫颈腺鳞癌的治疗方案,为临床治疗提供参考。方法：收集2002年1月至2007年12月收治的44例宫颈腺鳞癌患者的临床资料进行回顾性分析（研究组）,选取同期88例宫颈腺癌作为对照组,用卡方检验、Kaplan-Meier法、log-rank检验、Cox回归模型进行统计学分析。结果：宫颈腺鳞癌患者肿瘤直径〉4cm占47.7%,对照组占28.4%,差异有统计学意义（P〈0.05） 肿瘤组织为低分化者研究组占56.8%,对照组占30.7%,差异有统计学意义（P〈0.05）。单因素分析显示肿瘤直径（P=0.011）、FIGO分期（P=0.013）、间质浸润（P=0.05）、淋巴结转移（P=0.017）与预后有关。多因素分析显示FIGO分期（P=0.032）和淋巴结转移（P=0.017）是影响预后的独立因素。2年总生存率和2年无瘤生存率宫颈腺鳞癌患者分别为83.3%和80.7%,宫颈腺癌患者分别为87.1%和85.0%,差异无统计学意义（P〉0.05）。结论：宫颈腺鳞癌具有瘤体大、组织学分化差的临床特点,FIGO分期和淋巴结转移是影响宫颈腺鳞癌预后的重要因素,腺鳞癌预后与腺癌无差异。

英文摘要：

Background and Objective：The incidence of cervical adenosquamous carcinoma is relatively low.This study was to analyze the clinicopathologic characteristics and prognostic factors of cervical adenosquamous carcinoma.Methods：Clinical data of 44 cervical adenosquamous carcinoma patients and 88 cervical adenocarcinoma patients （control）,treated from January 2002 to December 2007,were analyzed using Chi-square test,Kaplan-Meier method,log-rank test,and Cox regression model.Results：The proportion of large tumors （maximum diameter 〉4 cm） and that of poorly-differentiated tumors was significantly higher in the cervical adenosquamous carcinoma group than in the cervical adenocarcinoma group （47.7% vs.28.4%,56.8% vs.30.7%,respectively,P 〈0.05）.Univariate analysis showed that tumor size （P=0.011）,FIGO stage （P=0.013）,depth of stromal invasion （P=0.05）,and lymph node metastasis （P=0.017） were correlated with prognosis,and multivariate analysis showed that FIGO stage and lymph node metastasis were independent prognostic factors.There was no significant difference of 2-year overall or disease-free survival rates between the two groups （P〉0.05）.Conclusions：Cervical adenosquamous carcinoma is characterized by large tumor size and poor differentiation.FIGO stage and lymph node metastasis are significant prognostic factors.There is no difference in prognosis between cervical adenosquamous carcinoma and cervical adenocarcinoma.