中文摘要：

目的 探讨血管紧张素Ⅱ1型受体（AT1R） A1166C多态与血压的关系。方法 在云南省大理市邀请某工厂所有无血缘关系的在职和退休职工参与本研究，最终有1466名受检者纳入统计分析。运用标准化问卷收集饮酒、吸烟、药物服用史等。抽提DNA，用SNaPshot方法检测AT1R基因型。结果 1466名受检者包括556名（37.9%）女性，485名（33.1%）超重/肥胖者，468名（31.9%）高血压患者，其中212名（45.3%）接受降压治疗。AT1R AA、CA和CC三个基因型的频率分别为90.5%、9.4%和0.1%。基因型（AA、CA＋CC）和等位基因频率分布在血压正常者和高血压患者之间的差异没有统计学意义（P〉0.05）。在未调整和调整协变量前后，不同基因型之间收缩压、舒张压和脉压差别均无统计学意义（P〉0.05）。进一步分析发现，AT1R A1166C多态和体质指数交互作用影响收缩压（Pint＝0.002）和脉压（Pint＝0.02）。只有在体质指数的最高四分位数组（＞25.8 kg/m2），C等位基因携带者的收缩压（P＝0.02）和脉压（P＝0.009）显著高于AA型纯合子。结论 AT1R A1166C多态与体质指数交互作用影响收缩压和脉压水平。

英文摘要：

Aim To explore the associations of angiotensin Ⅱ type 1 receptor （AT1R） A1166C variant with blood pressure in Chinese. Methods We invited all unrelated employees and retired workers to take part in this study, and 1466 participants were included in the present analysis. Standardized questionnaires were used to collect information on alcohol consumption, smoking habits, and use of medications. The AT1R genotype was determined by SNaPshot method. Results One thousand four hundred and sixty six participants included 566 （37.9%） women, 485 （33.1%） overweight/obese participants, 468 （31.9%） hypertensive patients, of whom 212 （45.3%） took antihypertensive treatment. The frequencies of AA, CA and CC were 90.5%, 9.4% and 0.1%, respectively. There was no significant difference in the distributions of genotypes and alleles between participants with normal blood pressure and hypertensive patients （P〉0.05）. Furthermore, there was no significant difference in systolic and diastolic blood pressure and pulse pressure between genotypes before and after adjusted for covariates （P〉0.05）. We found significant interaction between the A1166C variant and body mass index on systolic blood pressure （Pint=0.002） and pulse pressure （Pint=0.02）. Only among participants in the highest quartile of body mass index （〉25.8 kg/m2）, C allele carriers had significantly higher systolic blood pressure （P=0.02） and pulse pressure （P=0.009） than AA homozygotes. Conclusions Significant interactions were observed between AT1R A1166C variant and body mass index on systolic blood pressure and pulse pressure.