中文摘要：

TAM受体是最新的一个受体酪氨酸激酶（Recepter tyrosine kinases，RTKs）亚家族，包括三个成员：Tyro3、Axl和Mer。它们结构相似，具有共同的配体Gas6和Protein S。TAM受体广泛表达于哺乳动物的多种组织中，在神经、免疫、造血、生殖等系统发挥重要的生物学功能，可以调节多种细胞的存活、增殖与分化。对其功能及作用机理的研究近年来取得了较大进展，并受到广泛的重视。本文旨在概述TAM受体的研究进展，着重介绍其生物学功能的作用机理，特别是其介导的信号通路。

英文摘要：

TAM receptors are the latest identified receptor tyrosine kinases （RTKs） subfamily, which includes three members： Tyro3, Axl and Mer. Two high homologous proteins-Gas6 and Protein S, which belong to vitamin K-dependent proteins, are common biological ligands of TAM receptors. TAM receptors are widely expressed in various mammalian tissues, and have been demonstrated to be functional in nervous, immune, reproductive and hematopoietic systems. They play important roles in regulating survival, proliferation and differentiation of cells. In this review, we highlight functions and mechanisms of TAM receptors. Particularly, we illuminate intracellular siganalling pathways regarding to individual TAM receptors.