中文摘要：

自从1990年过氧化体增殖剂激活受体（peroxisome proliferators—activated receptors，PPARs）被发现后，其各种生物学功能被陆续地阐明。研究表明，PPARs可能在基因转录水平对梗阻性黄疸肝脏损伤起到保护作用，这种保护作用的具体机制已经成为研究的热点。本文就此问题对近年来的研究进展做一综述。

英文摘要：

Since its initial discovery in 1990, the diverse roles of the peroxisome proliferator-activated receptors （PPARs） have been elucidated. PPARs may act the protective effects against the obstructive jaundice-induced liver damage by regulating gene transcription. This protective mechanisms have becom the focus. This review will outline the advancement in this field.