中文摘要：

目的：通过慢性间歇缺氧的方法建立大鼠心房颤动（AF）纤维化模型。方法：16只SD雄性大鼠随机分为慢性间歇缺氧组（模型组）和空白对照组,每组8只,慢性间歇缺氧组大鼠置于低压氧舱中,循环充入氮气与氧气,每次循环时间为300 s,其中充入氮气时间为210 s,充入氧气时间为90 s,使舱内氧浓度波动于8%-21%之间。空白对照组普食喂养,未作干预。第31天称重后行超声心动图检查评价心功能并处死大鼠,留取组织进行相应实验,Masson染色并分析心房纤维化程度。结果：模型组大鼠心房纤维化程度与对照组相比明显增加（P〈0.05）,模型组大鼠肺动脉压力与对照组相比明显升高。结论：慢性间歇缺氧可导致大鼠心房纤维化,其可以被用来作为研究AF与心房结构重构的重要研究平台。

英文摘要：

Objective： To establish fibrosis model of atrial fibrillation（AF）through chronic intermittent hypoxia in rat. Methods： Sixteen SD male rats were randomly divided into chronic intermittent hypoxia group（model group） and control group（n = 8）. Model group rats were placed in a chamber, which was periodically filled with nitrogen and oxygen. The time for filling with nitrogen was 210 s, and the time for filling oxygen was 90 s, Concentration of oxygen in chamber was between 8% and 21%. Control group was not intervened. The rats were sacrificed after the examination of echocardiography in the thirty-first day. The tissue of atrial was taken for Masson stain to analyze the degree of atrial fibrosis. Results： The degree of atrial fibrosis in model group was significantly higher than that in control group（P0.05）. The pressure of pulmonary artery in model group was significantly higher than that in control group. Conclusion：Chronic intermittent hypoxia can lead to atrial fibrosis in rats, which can be used as an important research platform for AF and atrial remodeling.