中文摘要：

调查 Shaoyao Gancao 煎的效果的目的(， SGD ) 在在老鼠的静脉内地管理的 paclitaxel 的 pharmacokinetics 上。方法 Paclitaxel 静脉内地予老鼠(3 mg/kg ) 被以与或没有 SGD (752 mg/kg，一单个天或 14 连续的天预告的处理) 的伴随物管理。在浆液的 paclitaxel 用简单、快速的极端表演液体层析(UPLC ) 被确定为 pharmacokinetic 学习的方法。pharmacokinetic 参数用计算机程序 DAS 2.0 经由一个非分隔空间模型被计算。结果 paclitaxel 的 pharmacokinetic 参数显著地与 SGD 响应预告的处理的 14 连续的天被改变。在曲线下面的区域(AUC _0-t, 从 4 820

英文摘要：

Objective：To investigate the effect of Shaoyao Gancao Decoction（芍药甘草汤,SGD）on the pharmacokinetics of intravenously administered paclitaxel in rats.Methods：Paclitaxel was intravenously administered to rats（3 mg/kg）with or without the concomitant administration of SGD（752 mg/kg,a single day or 14 consecutive days pretreatment）.The paclitaxel in the serum was quantified using a simple and rapid ultra performance liquid chromatography（UPLC）method for the pharmacokinetic study.The pharmacokinetic parameters were calculated via a non-compartment model using the computer program DAS 2.0.Results：The pharmacokinetic parameters of paclitaxel were significantly altered in response to 14 consecutive days of pretreatment with SGD.The area under the curve（AUC0-t,from 4 820±197 to 4 205±186 ng·m L-1·h-1）and AUC0-∞（from 5 237±280 to 4 514±210 ng·m L-1·h-1）significantly decreased in response to the 14-day pretreatment with SGD.The values of V dss（L/kg）were 10.74±1.08 and 9.35±0.49,those of CL（L/kg）were0.67±0.03 and 0.57±0.03 and the t1/2（h）values were 11.17±0.84 and 11.32±0.93,respectively,for the14-day SGD pretreatment and intravenous paclitaxel alone.The AUC0-t and AUC0-∞values decreased by13%and 14%（P〈0.01）,respectively.The area under the curve decreased significantly（P〈0.01）,and the total clearance increased by 1.2-fold（P〈0.01）,after 14 consecutive days of pretreatment with SGD.A single-day pretreatment with SGD did not significantly affect the pharmacokinetic parameters of paclitaxel.Conclusions：SGD administration for 14 consecutive days increased the metabolism of paclitaxel,while a 1-day pretreatment had little effect.The results would contribute important information to the study on interaction between Chinese medicines and chemotherapy and also help to utilize SGD better in the adjunctive therapy of cancer patients.