中文摘要：

目的探讨伴有嗅觉障碍的慢性鼻-鼻窦炎（CRS）（伴有/不伴有鼻息肉）患者经鼻内镜手术后嗅觉的转归及其生活质量（QOL）的改善情况。方法伴有嗅觉障碍的慢性鼻-鼻窦炎患者44例,其中伴有鼻息肉的患者33例,不伴有鼻息肉的患者11例,于术前行鼻部CT检查（冠状位＋矢状位）,Lund-Mackay CT评分,并分别于术前、术后4周及12周行T＆T嗅觉测试、嗅觉VSA评分及鼻腔鼻窦结局测试（SNOT-20）。结果术后4周嗅觉T＆T测试59.5%的患者嗅觉有改善,术后12周73.0%的患者嗅觉有改善。术后4周嗅觉vas评分有77.3%的患者嗅觉有改善,术后12周86.4%的患者嗅觉有改善。统计学显示嗅觉T＆T测试及嗅觉VAS评分术后4周及12周的得分较术前明显改善（P〈0.000 1）,术后4周及12周差异无统计学意义（P=0.720,0.147）。SNOT-20评分术前与术后4周及12周均有统计学差异（P〈0.000 1）,术后4周与12周差异无统计学意义（P=0.055）。术前LundM ackay CT评分与T＆T嗅觉测试、嗅觉VAS评分呈正相关（r=0.569,P〈0.000 1;r=0.782,P〈0.000 1）。结论鼻内镜术后患者嗅觉及QOL均明显改善,术后4周与12周改善程度差异无统计学意义。患者术前病变范围与嗅觉障碍程度呈正比。

英文摘要：

Objective To explore the improvements of olfaction and quality of life （QOL） of the chronic rhinosinusitis （CRS） patients （ with / without nasal polyps） with olfactory disorders. Methods 44 CRS patients with olfactory dis- orders were involved in this study and accepted CT scanning and Lund-Mackay CT score investigation before treat- ments. VAS score, SNOT-20 score and T＆T test were taken before the operation, and 4 weeks and 12 weeks after the operation. Results In the T＆T test, there were 59.5% and 73.0% of the patients whose olfaction were improved 4 and 12 weeks after the operation. The improvement rates were 77.3% and 86.4% in the VAS score. There were statis- tical difference between the pre-operation and post-operative 4 and 12 weeks（ P 〈 0.0001 ）in the T＆T test and the VAS score, while the difference between the 4 weeks and 12 weeks after the operation were statistical insignificant （P = 0. 720,0. 147 ）. There was statistical difference between the pre-operation and post-operative 4 and 12 weeks （P 〈 0. 000 1 ） in the SNOT-20 test, while the difference between the 4 weeks and 12 weeks after the operation was statistical- ly insignificant （ P = 0. 055 ）. Lund-Mackay CT score, T ＆ T test, and VAS scores were positively correlated （ r = 0. 569,P 〈 0. 000 1 ; r = 0. 782, P 〈 0. 000 1 ）. Conclusion The olfaction and QOL of the patients significantly improve after endoscopic sinus surgery, and the difference between the 4 weeks and 12 weeks after the operation is statistically insignificant, The extent of the disease in the CRS and the degree of olfactory disorder are positively correlated.