目的:观察内膜方对促排卵周期中肾虚型不孕症患者子宫内膜容受性的影响。方法:收集促排卵周期中子宫内膜发育不良的肾虚型不孕症患者90例,在下一个周期中随机分为两组,其中治疗组45例,从月经周期第5天起服用内膜方,每日1剂,直至排卵日;对照组45例,月经第5天开始口服戊酸雌二醇片,每日2mg,直至排卵日。以上两组均在排卵日监测成熟卵泡的数量、子宫内膜类型及厚度和子宫内膜下的血流参数,同时随访两组的妊娠结局。结果:两组患者子宫内膜厚度及类型用药后有所改善,而治疗组与对照组之间比较差异无统计学意义(P〉0.05);用药后两组患者子宫内膜下血流参数比较差异有统计学意义(P〈0.05);治疗组成熟卵泡数量、妊娠率均高于对照组,差异有统计学意义(P〈0.05)。结论:内膜方能促进促排卵周期中子宫内膜的生长,改善子宫内膜类型及子宫内膜下血流情况,促进胚胎着床,提高临床妊娠率。
Objective: To observe the effects of Neimofang on endometrial receptivity of kidney deficiency type patients with infertility in the ovulatory cycle. Method: A sample of 90 kidney deficiency type patients with infertility whose endometrium was undergrown was collected, in the next cycle they were randomly divided into 2 groups: 45 cases of treatment group, taking a course of treatment of Neimofang fi'om the 5th day of menstrual cycle, one dose daily, until the ovulation day; 45 cases of control group, taking estradiol valerate tablets from the 5th day of menstrual cycle, 2rag daily, until the ovulation day. Monitor the number of mature follicle, type and thickness of endometrium and blood flow parameters under endometrial on the ovulatory day, while follow-up pregnancy outcomes of the two groups. Resuh: After the administration of drugs, endometrial thickness and type of the two groups have been improved, and the comparative differences between treatment and control groups were not statistically significant ( P〉0.05 ); blood flow parameters under, endometrial of treatment was lower than that of the control group ( P〈0.05 ); the treatment group and control group had a significant difference in the number of mature follicle( P〈0.05 ) the pregnancy rate of the treatment group was significantly higher than that of the control group ( P〈0.05 ). Conclusion : Neimofang can promote the growth of the endometrium in ovulatory cycle, improve the type of endometrium and blood flow parameters under endometrium, facilitate embryo implantation, and then increase clinical pregnancy rates.