中文摘要：

有丝分裂原活化蛋白激酶激酶激酶（mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3,MEKK3）是MAP3K（mitogen-activated protein kinase kinase kinase）家族的丝氨酸/苏氨酸蛋白激酶,它在哺乳类动物的各种组织中广泛表达。该蛋白激酶能够有效激活有丝分裂原活化蛋白激酶（mitogen-activated protein kinase,MAPK）和NF-κB信号通路,与多种肿瘤的发生与发展密切相关。本文将从其结构、蛋白磷酸化、信号传导、免疫调节及与肿瘤的关系等方面对MEKK3的研究进行相关综述。

英文摘要：

Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3（MEKK3） is a kind of serine/threonine protein kinase in the mitogen-activated protein kinase kinase kinase（MAP3K） family,which is widely expressed in various tissues in mammals.The protein kinase can effectively activate the MAPK and NF-κB signaling pathway.At the same time,it＇s closely linked with the occurrence and development of a variety of tumors.This review will summarize the progress in the study of the structure,protein phosphorylation,signal transduction of MAP3K and its relation with the immune regulation and the development of the tumor.