中文摘要：

基于酸碱作用,将手性伯胺与质子酸原位结合制得有机小分子催化剂,并用于醛与醛的不对称Cross-aldol反应.与一般手性仲胺催化剂不同,该类伯胺催化剂得到的是顺式选择性构型的Cross-aldol产物,其产率达90%,顺反比和ee值分别为9：1和90%.相比而言,采用简单易得的（1S,2S）-（＋）-环己二胺即可得到较高选择性的顺式产物.

英文摘要：

Based on the ＂acid-base＂ interaction strategy,organocatalysts for the asymmetric cross-aldol reaction were synthesized by the in situ combination of chiral primary amines with protonic acids.Unlike general secondary amine catalysts that give anti-selective products,as-prepared primary amine catalysts can give syn-selective cross-aldol products with high yield and high selectivity （up to 90% yield,90：10 syn/anti ratio,90% ee）.Compared with the complex synthesis of the reported catalysts,the primary amine catalyst that gave the best results was easily prepared using commercial available （1S,2S）-（＋）-cyclohexanediamine.