中文摘要：

目的：探讨HIA-DR、DQ基因多态性与遵义地区汉族流行性出血热（EHF）的关联性。方法：采用群体研究方法，应用聚合酶链反应-序列特异性引物（PCR-SSP）技术对100例流行性出血热患者（患者组）和100例健康对照者（健康对照组）进行HIA-DR、DQ基因分型，比较其等位基因频率（GF），并计算其相对危险度（RR）。结果：EHF患者组HLA-DRB1＊16基因频率较对照组明显增高（Pat=3．58，χ^2=4．916，P=0．0266〈0．05）；患者组HIA-DQ各等位基因频率与对照组比较差异无显著性。结论：研究提示在遵义地区汉族人群中，HLA-DRB1＊16基因与EHF呈正相关，HLA-DRB1＊16基因可能是EHF的易感基因。

英文摘要：

Objective：To explore the association between HLA-DR,DQ allele polymorphisms and onset of epidemic hemorrhagic fever （EHF） among Han Nationality in Zunyi area.Methods： Using group study,HIA-DR and DQ genotyping was conducted in 100 EHF cases and 100 controls among Han Nationality in Zunyi area with polymerase chain reaction-sequence specific primer（PCR-SSP）, GF （gene frequency） and RR （relative risk） were calculated and compared.Results： The frequency of HLA-DRB1 ＊ 16 in patients with EHF was higher than in the control group（RR = 3.58, χ^2 = 4. 916, P = 0.0266 〈 0.05）. There was no significant difference between the frequency of allele HLA-DQ in patients and in control group. Conclusion：It can be cued that HLA-DRB1 ＊ 16 gene is positively related to EHF in Zunyi Han nationality, HLA-DRB1 ＊ 16 gene may be a predisposing gene to EHF.