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两株新种放线菌次生代谢产物中的环二肽(英文)
  • ISSN号：1672-3651
  • 期刊名称：Chinese Journal of Natural Medicines
  • 时间：2011
  • 页码：78-80
  • 分类：TQ46[化学工程—制药化工]
  • 作者机构：[1]教育部自然资源药物化学重点实验室,云南大学化学科学与工程学院,昆明650091, [2]云南大学云南省微生物研究所,昆明650091
  • 相关基金：国家自然科学基金重点资助项目（No.U0932601）,国家自然科学基金资助项目（No.81060263）; 国家大学生创新性实验项目
  • 相关项目：从云南特境放线菌新物种中发现抗癌新化合物及作用机制研究
作者： 刘超|杨雪琼|丁中涛|赵立兴|曹艳茹|徐丽华|杨亚滨|
关键词： 环肽, 放线菌, Streptosporangium, Kribbella, Peptides, Actinomycetes, Streptosporangium, Kribbella
中文摘要：

目的：研究两株新种放线菌次生代谢产物。方法：采用柱层析方法分离纯化,根据理化性质和光谱数据鉴定化合物的结构。结果：从白色球孢囊菌分离鉴定了4个环二肽为环（L-脯氨酸-L-天冬酰氨）（1）、环（L-脯氨酸-L-丝氨酸）（2）、环（L-脯氨酸-L-丙氨酸）（3）、环（L-脯氨酸-L-苏氨酸）（4）。从云南韩国生工菌分离鉴定了3个环二肽为环（L-脯氨酸-L-丝氨酸）（2）、环（L-脯氨酸-L-苏氨酸）（4）、cyclo-di-Nδ-acetyl-L-ornithyl（5）。结论：化合物5为新天然产物。首次对化合物1,5的碳氢谱数据进行了归属。所有化合物均首次从该两种放线菌中分离得到。其中化合物1对慢性粒细胞白血病细胞株有一定的细胞毒活性。

英文摘要：

AIM：To investigate the secondary metabolites of two novel actinomycetes in order to find new compounds or effective components.METHODS：Compounds were isolated on silica gel column.The structures were elucidated on the basis of spectral data.RESULTS：Four cyclodipeptides were isolated from the fermentation broth of Sphaerisporangium album,and their structures were determined as cyclo （L-Pro-L-Asn） （1）,cyclo （L-Pro-L-Ser） （2）,cyclo （L-Pro-L-Ala） （3）,and cyclo （L-Pro-L-Thr） （4）.Three cyclodipeptides were isolated from the fermentation broth of Kribbella yunnanensis,and their structures were determined as cyclo （L-Pro-L-Ser） （2）,cyclo （L-Pro-L-Thr） （4）,and cyclo-di-Nδ-acetyl-L-ornithyl （5）.CONCLUSION：5 was a new natural compound.The full assignments of 1H and 13C NMR chemical shifts for 1 and 5 were obtained by 2D NMR firstly.All compounds were isolated from these two actinomycetes for the first time.When tested against tumor cell line panel （k563）,1 displayed cytotoxicity.

同期刊论文项目
从云南特境放线菌新物种中发现抗癌新化合物及作用机制研究
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