中文摘要：

用放射性核素^111In^3＋标记的肽核酸（PNA）为探针，分别检测与PNA序列互补的单链寡聚核苷酸、pUC19-C1质粒结合形成双螺旋的情况．结果表明，PNA不仅能够与游离单链的互补核酸形成稳定的双螺旋；还在有PNA开链剂存在的情况下，能够与靶位质粒特异性结合．以放射性标记的PNA可作为检测目标基因片断的有效分子探针．

英文摘要：

The radio-111In3＋ labelled peptide nucleic acid （PNA） was used as molecular probe and the pUC19-C1 plasmid which contains the target site of the PNA probe was constructed. The results show that PNA forms a stable double helix with not only the complementary single-stranded nucleic acid but also the plasmid in the presence of PNA opener. It is suggested that radio-labelled PNA probe can be used to detect target DNA in genes.