准备 nanoparticle 穿的周期的 Au@metal 器官的框架(MOF )(MIL-100 (Fe )) 的一个灵巧、便宜的方法被开发。数组用单层在 situ 被制作是的胶体的晶体模板,在底层上由 Au 免职列在后面,并且退火。MIL-100 (Fe ) 涂层用简单溶剂在 nanospheres 上被使用热过程。准备周期的 Au@MIL-100 (Fe ) nanoparticle (NP ) 数组被二座山峰在可见系列描绘。第一座山峰表示 Au nanospheres 的表面电浆子回声(SPR ) ,和另外的山峰,或衍射达到顶点,在 NP 数组从周期的结构发源。在有 3-aminophenylboronic 酸 hemisulfate (PBA ) 的修正以后, Au@MIL-100 (Fe ) NP 数组与好选择展出了敏感回答到不同葡萄糖集中。这些回答能由于在 PBA 和葡萄糖分子之间的强壮的相互作用。衍射山峰在低葡萄糖集中(不到 12 公里) 是敏感的,而 SPR 山峰很快在高集中反应了。山峰因此在不同集中区域为葡萄糖察觉表明了令人满意的互补敏感。这些结果能被用来开发一个双隧道的生物传感器。我们也创造了一张标准图,它能被用来高效地监视血葡萄糖层次。建议策略能被扩大与不同识别代理人用 Au@MIL-100 (Fe ) NP 数组 functionalized 开发不同双隧道的传感器。
A facile and low-cost method to prepare periodic Au@metal-organic framework (MOF) (MIL-100(Fe)) nanoparticle arrays was developed. The arrays were fabricated in situ using monolayer colloidal crystals as templates, followed by Au deposition on substrates, and annealing. MIL-100(Fe) coatings were applied on the nanospheres using a simple solvent thermal process. The prepared periodic Au@MIL-100(Fe) nanoparticle (NP) arrays were characterized by two peaks in the visible spectra. The first peak represented the surface plasmon resonance (SPR) of the Au nanospheres, and the other peak, or the diffraction peak originated from the periodic structure in the NP array. After modification with 3-aminophenylboronic acid hemisulfate (PBA), the Au@MIL-100(Fe) NP arrays exhibited sensitive responses to different glucose concentrations with good selectivity. These responses could be due to the strong interaction between PBA and glucose molecules. The diffraction peak was sensitive at low glucose concentrations (less than 12 mM), whereas the SPR peak rapidly responded at high concentrations. The peaks thus demonstrated satisfactory complementary sensitivity for glucose detection in different concentration regions. These results can be used to develop a dual-channel biosensor. We also created a standard diagram, which can be used to efficiently monitor blood glucose levels. The proposed strategy can be extended to develop different dual-channel sensors using Au@MIL-100(Fe) NP arrays agents. functionalized with different recognition