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加味参附汤对肾阳虚肺纤维化大鼠凋亡相关因子caspase-3和Bcl-2表达的影响
  • ISSN号:0256-7415
  • 期刊名称:新中医
  • 时间:2014
  • 页码:178-180
  • 分类:R749.16[医药卫生—神经病学与精神病学;医药卫生—临床医学]
  • 作者机构:[1]湖北中医药大学,武汉430065
  • 相关基金:国家自然科学基金资助项目(81102529)
  • 相关项目:Klotho蛋白与肾脾阳虚致衰机制相关性的研究
中文摘要:

目的:比较几种常见肝郁动物模型的稳定性,重复性,为后续的基础研究提供合理的动物模型。方法:采用夹尾法、束缚筒及束缚架法造模,记录并分析大鼠行为变化,评价模型质量。结果:各模型组大鼠的糖水消耗量和糖水偏爱率显著降低,与正常组比较均有统计学意义(P〈0.01或P〈0.05)。束缚架组、束缚筒组大鼠不动时间明显延长及挣扎次数明显少于正常对照组,均有统计学意义(P〈0.01)。束缚架组、束缚筒组旷场实验各行为指标与正常对照组比较均有统计学意义(P〈0.01或P〈0.05)。结论:束缚架组、束缚筒组模型制备方法可行性较好。

英文摘要:

Objective: To explore the stability and repeatability of the animal models of liver - qi stagnation and provide some experimental basis for subsequent basis studies. Methods:Using clip tail method, bound cylin- der of rats and bound rack to make models, recorded and analyzed rats behavior changes, evaluated quality of model. Results: The sugar water consumption and preference rate of rats which in different model group were sig- nificantly decreased, compared with the blank group ,there were significant differences(P 〈 0. 01 or P 〈 0. 05) . The fixed time was obviously prolonged and numbers of struggle of rats in bound rack group and bound cylinder group were significantly less than those in normal control group, the behavior index of bound rack group and bound cylinder group had significant difference in open field test to compare with those of normal group. ( P 〈 0. 01 or P 〈 0. 05 ). Conclusion: The bound rack group and bound cylinder group were more feasibility by evaluation.

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期刊信息
  • 《新中医》
  • 北大核心期刊(2008版)
  • 主管单位:国家中医药管理局
  • 主办单位:广州中医药大学 中华中医药学会
  • 主编:
  • 地址:广州市番禹区广州大学城外环东路232号
  • 邮编:510006
  • 邮箱:xzybjb@gzhtcm.edu.cn
  • 电话:020-39359588
  • 国际标准刊号:ISSN:0256-7415
  • 国内统一刊号:ISSN:44-1231/R
  • 邮发代号:46-38
  • 获奖情况:
  • 全国优秀科技期刊,全国中医药优秀期刊,中国自然科学核心期刊,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2000版)
  • 被引量:42405