中文摘要：

羟基磷灰石和胶原是人体骨的主要成分，近年来，制备纳米羟基磷灰石／胶原复合材料已成为目前生物材料研究的热点之一。海藻酸钠是一种酸性的多聚糖，具有良好的生物相容性，目前已经被广泛应用于化学、生物、医药、食品等领域；海藻酸钠能与钙离子交联，可进一步获得具有良好弹性性能的网状结构。

英文摘要：

A composite gel composed of collagen, alginate and synthetic HA powder was formed by using collagen assembly, and freeze-drying of the composite gel gave rise to collagen-alginate-HA porous materials. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and Ultra-violet spectroscopy were used to characterize the physiochemieal properties of the prepared materials and to reveal the possible interactions between molecular species. The results indicated that the scaffolds had interconnected porous structure with typical pores ranging between 200-600μm. Inorganic phase, poorly crystallized hydroxyapatite, was formed uniform dispersion with the organic substances. The introduction of alginate, to some extent, influenced the collagen assembly process. The materials prepared in this study could be a promising scaffolds for bone tissue engineering.