中文摘要：

目的：研究抗癌药物羟基喜树碱（HCPT）新剂型羟基喜树碱脂质体（LHCPT）在Beagle犬体内的毒物代谢动力学,探讨该药物是否在血液中有蓄积作用。方法：采用HPLC-荧光检测法测定全血中LHCPT的浓度。结果：在第1天和连续给药第30天后Cmax和AUC值存在剂量相关性;药物半衰期t1/2不同剂量之间无显著变化（P〉0.05）。AUC、Cmax、t1/2值多次给药与单次给药后比较,同剂量下均未见显著提高（P〉0.05）。结论：LHCPT连续静脉给药后未见血液中有明显蓄积现象。

英文摘要：

Objective：To study the toxicokinetics of LHCPT in Beagle dogs by intravenous infusion,and discuss the accumulative effects of LHCPT in blood.Methods：HPLC with fluorescence detection was used to analyze drug concentration in whole blood.Results：Cmax and AUC were increased in a dose-dependent manner both after 1st day and 30th day;and there was no statistical significance in t1/2 of different doses（P 〉 0.05）.Compared with single administration with repetition,there were no obvious changes of AUC,Cmax and t1 /2 of the same dose（P 〉 0.05）.Conclusion：LHCPT has no significantly accumulative effects after successive intravenous administration.