中文摘要：

目的：探讨电针影响围绝经期综合征大鼠的最佳时机。方法：复制大鼠去卵巢模型,分 5 个不同时期进行电针干预,观察不同干预时期大鼠的耐热能力、体力和睡眠功能。结果：电针能增强各时期围绝经期综合征大鼠的耐热能力、体力,缩短入睡时间,延长睡眠时间;以造模前 7 d组、造模后 1 d组和造模后 8 d组为佳,而造模后 15 d组和造模后 22 d组次之。结论：电针对围绝经期综合征大鼠的预防和前期干预效果为佳,随着电针介入时间的推迟,疗效呈下降趋势,提示电针干预围绝经期综合征大鼠以预防和早期治疗更重要。

英文摘要：

Objective： To explore the best opportunity for electroacupuncture therapy to treat perimenopause syndrome. Methods： The rats were duplicated as ovariectomized model and took the electroacupuncture therapy at 5 different periods. The heat-resistance ability, physical strength and sleeping ability of the rats at different intervention time were recorded. Results： For the rats with perimenopause syndrome at all periods, the electroacupuncture could promote the beat-resistance and the physical strength, shorten the sleep latency and prolong the sleeping time. The results of the rats in the 7 d pre-modeling group, 1 d post-modeling group and 8 d post-modeling group were the best, followed by the results of 15 d post-modeling group and 22 d post-modeling group. Conclusion： The prevention and early intervention of electroacupuncture on the rats with perimenopanse syndrome were satisfied and the effect declined with a later intervention time, indicating the importance of prevention and early intervention.