中文摘要：

钛（Ti）和丝素蛋白（SF）具有良好的生物相容性与较好的机械强度,在医学临床及生命科学领域得到了广泛的应用。介绍了羟基磷灰石（HA）、钛和丝素蛋白的特点及其在骨替代材料中的应用,总结了仿生矿化法制备HA的方法,包括：仿生浸泡法、机械化学法、共沉淀法与分子自组装法。分析了HA/Ti复合材料的仿生矿化过程,主要包含钛基体的官能团化和晶体的成核与生长。综述了以膜、溶液、粉末及纤维等不同形式的SF仿生制备HA/SF复合材料的研究现状,并对HA/SF/Ti复合材料仿生矿化的发展方向进行了探讨。

英文摘要：

Titanium （Ti） and silk fibroin （SF） have good bioeompatibility and mechanical strength and are widely applied in medical clinical and life science field. This paper introduces characteristics of Hydroxyapatite （HA）, Ti and SF and their application in bone substitution material, summarizes methods for the preparation of HA with biomimetic mineralization method, including biomimetie immersion method, mechanical and chemical methods, coprecipitation method and molecular self-assembly method, analyzes biomimetic mineralization process of HA/Ti composite material, mainly including functionalization of titanium substrate and nucleation and growth of crystal, summarizes the research status of biomimetic preparation of HA/SF composite material with different forms of SF such as membrane, solution, powder and fiber and discusses the development direction of biomimetic mineralization of HA/SF/Ti composite material.