中文摘要：

过量使用的罗红霉素等抗生素会经不同途径流入水体,溶入沉积物,造成对水生生态系统的危害.本文将底栖动物中国圆田螺（Cipangopaludina chinensis）暴露于罗红霉素中,分别检测其胃、肝脏、肾脏、卵巢和肌肉组织中的红霉素-N-脱甲基酶（ERND）活性,来监测沉积物中抗生素对底栖生物的影响。结果表明,中国圆田螺主要组织微粒体中具有细胞色素P450亚型活性,但它们在中国圆田螺内的分布和活性不存在组织和器官差异性。连续给药2 d后中国圆田螺的肝脏、肾脏、胃和卵巢肌肉组织中的ERND的活性都会升高,呈现明显的剂量-效应关系,到第3天达到最高点,第4天却开始下降。其总体趋势是先促进后抑制,但不同浓度的罗红霉素引起的影响差异并不大。从对照组和各个实验组田螺的存活状况看来,罗红霉素作为一种抗生素,对中国圆田螺没有致死效应,但本实验所使用的250倍环境浓度、500倍环境浓度以及750倍环境浓度已经可以对田螺各组织中ERND活性产生明显的影响。

英文摘要：

Overuse of antibiotics, such as erythromycin through different ways go into the water, then into the sediment, causing harm to aquatic ecosystems. The benthic animal Cipangopaludina chinensis exposed to roxithromycin, were detected the ERND in the stomach, liver, kidney and ovary, examining the impact of roxithromycin on the activity of ERND enzyme in C. chinensis. The results showed that with the P450 isoform of cytochrome P450 activity, but they are in the distribution and activity of tissues and organs does not show difference in C. chinensis. Continuous administration to the C. chinensis,The ERND activity in liver, kidney, stomach, ovary and muscle tissue increased obviously, the dose effect relationship to reach the highest point in 3 days, and began to decline in 4 days. The overall trend is promoting more than restraining, but the inhibitory effects of different concentrations of roxithromycin have not great difference. From the point of view of the survival status of the control group and the experimental group of each snail, roxithromycin as an antibiotic, has no lethal effect on C. chinensis, but 250 times the concentration used in this experiment, 500 times and 750 times the concentration of environment can produce concentration has obvious influence on the ERND activity in tissues of C. chinensis.