中文摘要：

试验设计中往往会碰到带有趋势干扰因子的情形，这类趋势可以是由时间效应或空间效应引起的．本文探讨了幻方及纯幻方在带有趋势干扰效应设计中的若干应用．首先，利用幻方的组合性质，得到了一类设计因子与趋势干扰因子在参数估计上不混杂的设计：其次，采用纯幻方，进一步得到了多因子试验设计中的趋势无关设计；最后，给出了利用幻方和纯幻方构造相应趋势无关设计的基本方法，同时证明了运用同心幻方进行交叉验证的结果．

英文摘要：

There are always trend disturbances in design of experiment, which arise from the time trend or the space trend. In this paper, several applications of magic squares and perfect magic squares in trend free plans are discussed. Firstly, based on the combinational properties of magic squares, a class of plans which keep the estimations of design factors and trend disturbance factors independent are obtained. Moreover, by using perfect magic squares, the trend free plans with more factors are provided. Finally, some construction methods of such trend free plans are developed by magic squares and perfect magic squares. Meanwhile, the results between concentric magic squares and cross validation are also proved.