中文摘要：

观察吡格列酮对肥胖小鼠原代棕色脂肪（brown adipose tissue，BAT）细胞分化和功能基因表达的影响，并为治疗肥胖相关疾病寻找新思路。结果显示吡格列酮通过增强特异基因表达、促进分化成脂、提高线粒体功能等方面增强BAT细胞功能（P〈0．05）；这可能是吡格列酮改善机体代谢的重要原因。

英文摘要：

The effect of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells was detected for the new treatment of obesity and type 2 diabetes. The results showed that pioglitazone promoted the differentiation and function of brown adipocytes（ P〈0.05 ）.