中文摘要：

目的：研究藏药打箭菊对D-半乳糖胺（D-galactosamine,D-Gal）所致大鼠急性肝损伤的保护作用。方法：60只大鼠随机分为正常对照组、模型组、高中低剂量给药组、阳性对照组等6个组。给药组按18 g/kg、9 g/kg、4.5 g/kg剂量以打箭菊水提物灌胃;阳性对照组按50 mg/kg联苯双酯灌胃,每天1次,共7天。灌胃给药第6天下午,模型组和给药组按500 mg/kg体重腹腔注射D-Gal一次。第8天,末次给药24 h（腹腔注射36 h）后,测定血清生化指标,并测体重和肝脏重、脾重、胸腺重,求脏器系数,同时切取肝脏检测肝糖原,取肝组织作病理观察。结果：打箭菊18 g/kg、9 g/kg、4.5 g/kg剂量给药组均可显著降低急性肝损伤大鼠血清ALT、AST、ALP水平和TBA、T-Bil含量,促进血清中TP、ALB和肝组织中肝糖原的增加,且中低剂量给药组对肝重量增大和胸腺萎缩有抑制作用。病理检查结果也显示有明显的保肝作用。结论：打箭菊对D-Gal所致大鼠急性肝损伤有保护作用,其作用机制与多环节有关。

英文摘要：

Objective ： To study the protective effects of Pyrethrum tatsienense（Bur.et Franch.） Ling aqueous extract on acute hepatic injury induced by D-galactosamine（D-Gal） in rats.Methods： 60 rats were allocated to control group,model group,low,middle and high dosage group and Bifendate group randomly.In test groups,rats received either PT aqueous extract（18 g/kg,9 g/kg,4.5 g/kg） or Bifendate（50 mg/kg） by gastric perfusion daily for 7 consecutive days.In sixth day,D-Gal（500 mg/kg） was given to rats by intraperitoneal（ip） injection.The levels of ALT,AST,ALP,TBA,total bilirubin（T-Bil）,total protein（TP） and albumin（ALB） in serum were analyzed.The body weight,liver weight,spleen weight and thymus weight of each rat were measured.The hepatic glycogen content was analyzed individually.Liver tissue pathology was observed.Results ：PT aqueous extract can decrease the ALT,AST,ALP,TBA and T-Bil in serum,increase TP,ALB and hepatic glycogen content and restraining the enlargement of liver and the shrinkage of thymus,the middle and low dose can also reduce necrosis in pathological observation.Conclusion ：PT aqueous extract possesses the effects for protecting on acute hepatic injury induced by D-Gal in rats,its effects being related with multifarious mechanism.