中文摘要：

目的探讨体外受精（IVF）周期中注射人绒毛膜促性腺激素（HCG）日不同血清雌二醇（E：）水平对新鲜周期及随后胚胎冻融移植（FET）周期妊娠结局的影响。方法对2008年1月至2010年12月在上海交通大学医学院附属瑞金医院生殖医学中心接受常规IVF或卵胞浆内单精子注射（ICSI）助孕的820个周期进行回顾性分析，根据注射HCG日血清E，水平分为6组：A组（〈7340pmol／1．），B组（7340～〈11010pmol／L），C组（11010一〈14680pmoL／L），D组（14680-〈18350pmol／L），E组（18350～〈22020pmol／L）和F组（≥22020pmol/L）；为预防严重卵巢过度刺激综合征（OHSS）而放弃移植随后进行的首次FET周期，根据其取卵周期注射HCG日血清E，水平分为4组：I组（14680～〈18350prnol／L），Ⅱ组（18350～〈22020pmol／L），Ⅲ组（22020～〈25690pmol／L），Ⅳ组（~25690pmol／L），比较各组妊娠结局。结果随着E，水平的增加，受精率、卵裂率均呈增高趋势（P〈0．05）；新鲜移植（ET）周期-临床妊娠率、种植率及继续妊娠率A、B组略低，C、D、E、F组较高，但各组比较差异均无统计学意义（P〉0．05）。全胚冻存后的首次FET周期，Ⅰ～Ⅳ组临床妊娠率、种植率和继续妊娠率差异无统计学意义（P〉0．05）。总FET周期临床妊娠率（51．09％）和种植率（31．68％）明显高于总ET周期（38．90％，25．32％）（P〈0．05）。结论促排卵周期中HCG日血清E，水平与IVF结局没有显著相关性，与随后FET结局也没有显著相关性。

英文摘要：

Objective To evaluate the effect of different estradiol （ E2 ） concentrations on the day of human choiionic gon- adotrophin （HCG） administration on pregnancy outcome of fresh IVF cycles and subsequent frozen-thawed embryo trans- fer cycles. Methods 820 IVF/ICSI cycles between January 2008 and December 2010 performed in Reproductive Medi- cine Center of RuiJin Hospital Affilited of Shanghui Jiaotong University. were evaluated retrospectively. Serum E2 concen- trations on the day of HCG administration were categoiized into six groups： group A （ 〈 7340pmol/L）, group B （7340-〈ll010pmol/L）, group C （ll010- 〈 14680 pmol/L）, group D（ 14680- 〈 18350 pmol/L）, group E （18350 - 〈 22020 pmol/L）and group F （ ~〉 22020pmol/L）. The first frozen-thawed embryo transfer（FET） cycles in pa- tients with all-embryo cryopreservation to minimize the risk of severe OHSS were also categorized into four groups accord- ing to the E2 concentrations on HCG day in previous retrival cycles： group I （ 14680 - 〈 18350 pmol/L） , group ]I （ 18350 - 〈 22020 pmol/L）, group Ill （ 22020 ~ 〈 25690 pmol/L）, group 1V （ I〉 25690 pmol/L）. The pregnancy out- comes were analyzed. Results The fertilization rates and cleavage rates increased with the increasing E2 level（ P 〈 0. 05 ）. The pregnancy, implantation and ongoing pregnancy rates of groups A and B were lower than those of groups C - F. But there were no statistical significance （P 〉 0. 05 ）. The pregnancy, implantation and ongoing pregnancy rates of groups I - IV were similar （ P 〉 0. 05 ）. The pregnancy rate（51.09% ） and implantation rate（31.68% ） of first FET cycles in patients with all-embryo cryopreservation were higher dramatically than those of fresh cycles （38.90%, 25.32% ） （P 〈 0. 05 ）. Conclusion E2 levels on the day of HCG administration do not appear to affect pregnancy out- comes of IVF/ICSI or subsequent FET cycles.