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p53与间充质干细胞衰老及相关疾病研究进展
  • 分类：R593.241[医药卫生—临床医学;医药卫生—内科学]
  • 作者机构：[1]南通大学附属医院风湿免疫科,江苏226001
  • 相关基金：国家自然科学基金资助项目（81172841）; 江苏省“六大人才高峰”（第6批）项目; 江苏省卫生厅课题（2010Z005）; 江苏省教育厅自然科学基金（09KJB320010）; 南通大学研究生创新工程项目（13025043）
作者： 姜津霞（综述）[1], 顾志峰（审校）[1]
关键词： 间充质干细胞, 衰老, 系统性红斑狼疮, P53, 衰老相关β-半乳糖苷酶
中文摘要：

肿瘤抑制因子p53在防止肿瘤发生中起十分重要的作用,它可选择性调节靶基因和启动一系列的应激反应,诱导细胞周期停滞、凋亡与衰老。间充质干细胞（mesenchymal stem cells,MSCs）是一类属于中胚层的多能干细胞,具有自我更新、多向分化潜能、免疫调节及组织修复等多种潜能，已广泛用于临床研究与应用，而MSCs的衰老限制其进一步研究与运用。

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骨髓间充质干细胞衰老在系统性红斑狼疮患者发病中的作用
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