中文摘要：

目的 分析非霍奇金淋巴瘤（NHL）患者自体外周血造血干细胞移植前后淋巴细胞绝对数（ALC）、输注CD34＋细胞数与NHL疾病复发、无病生存（DFS）期、总生存（OS）时间的关系.方法 回顾性分析40例行自体外周血造血干细胞移植术的NHL患者的临床资料和实验室检查结果,对预处理前淋巴细胞绝对数（ALC-Pro）、移植后第15天淋巴细胞绝对数（ALC-15）以及输注CD34＋细胞数与NHL疾病复发、DFS和OS的关系,进行统计学处理和多因素线性回归分析.结果 ALC-Pro和ALC-15与NHL复发密切相关,ALC-Pro和ALC-15水平高的患者,复发率较低;通过Kaplan-Meier生存曲线和COX多因素回归分析,发现ALC-Pro和ALC-15均为影响患者DFS的重要因素;输注的CD34^＋细胞数虽然与ALC-15无关,但与患者DFS有关,输注CD34^＋细胞数多的患者其DFS期更长;ALC-Pro、ALC-15、CD34＋细胞均与NHL患者的OS有密切关系,移植前后ALC水平高、输注CD34＋细胞数量多的患者,其OS时间较长.结论 NHL患者自体外周血造血干细胞移植前后ALC水平和输注的CD34^＋细胞数,对于判断NHL复发、DFS、OS有一定参考意义,有可能成为NHL患者自体移植后预后判断的有价值的指标.

英文摘要：

Objective To evaluate the relationship of the absolute lymphocyte count （ALC） before or after autologous hematopoietic stem cell transplantation （AHSCT）, and the infused CD34＋ count with the relapse, disease-free survival （DFS）, overall survival （OS） in non-Hodgkin＇ s lymphoma （NHL） patients.Methods A retrospective analysis of the relationship of the absolute lymphocyte count before （ALC-Pro） or 15 days after （ALC-15） the AHSCT, and the infused CD34＋ cell count with the relapse, DFS, OS of NHL.Results ALC-Pro and ALC-15 were related to NHL relapse. The patients with high levels of ALC-Pro and ALC-15 had lower relapse rate. By Kaplan-Meier curve and COX multi-variable regression analysis, it was found that both ALC-Pro and ALC-15 were factors associated with the DFS. Patients infused high levels of CD34＋ cells had longer DFS. Patients with high levels of ALC-Pro, ALC-15, CD34＋ counts had longer OS.Conclusion ALC-Pro, ALC-15 and CD34＋ counts were significant in predicting relapse, DFS and OS for patients with NHL.