中文摘要：

目的：研究西他沙星对小鼠动物模型金黄色葡萄球菌（Staphylococcus aureus,SA）的抑制作用。方法：采用体外检测不同浓度西他沙星对SA 8325-4和SA 04018的杀灭作用,同时采用腹腔注射SA建立小鼠腹膜炎感染的动物模型,并在此基础上,通过腹腔给药的方式,检测不同剂量西他沙星给药后小鼠死亡率的变化。结果：西他沙星能够有效抑制SA生长;给予小鼠腹腔注射SA后,能够诱发小鼠急性腹膜炎,24 h后小鼠死亡率达87.5%,给予不同剂量的西他沙星可以有效降低小鼠死亡率。结论：西他沙星可以有效地抑制SA诱发的感染,对小鼠具有良好的保护作用。

英文摘要：

Objective： To study the protective function of sitafloxacin hydrate in murine acute peritonitis model induced by Staphylococcus aureus（SA）. Methods： The inhibition effects of sitafloxacin hydrate on SA 8325- 4 and SA04018 were determined in vitro. Murine acute peritonitis model was constructed with intraperitoneal injection of SA Mice were intraperitoneally injected with different dosages of sitafloxacin hydrate. The death ratios of mice from different groups were measured. Results： It was found that sitafloxacin hydrate could effectively inhibit the growth of SA8325-4 in vitro. Meanwhile, in murine acute peritonitis model, SA was lethal to mice. The death ration is 87.5% at 24 h after mice were challenged with SA. Furthermore, sitafloxacin hydrate was shown to decrease the death ratio of mice. Conclusion： Sitafloxacin hydrate can protect mice from infection caused by SA.