中文摘要：

利用多巴胺（DOPA）在有氧碱性溶液下形成聚多巴胺（PDA）的性质,以阿仑膦酸钠（ALD）为模型药物,作者制备了空白聚多巴胺纳米粒（PDA-NP）和载阿仑膦酸钠的聚多巴胺纳米粒（PDA-ALD-NP）,并对这两种纳米粒的粒径及Zeta电位、形貌、稳定性、载药量、体外释放、摩擦学性能以及细胞毒性等进行了初步考察.结果表明,二者平均粒径均小于102nm,分布较窄,Zeta电位均在-25mV左右.用扫描电子显微镜（SEM）观察两种纳米粒形貌,显示PDA-NP和PDA-ALD-NP光滑圆整.紫外可见分光光度法（UV-Vis）测得PDA-ALD-NP载药量为5.3%±1.2%,体外释放结果表明PDA-ALD-NP明显减缓了ALD的释放.体外稳定性实验结果显示,PDA-ALD-NP在水溶液和胎牛血清（FBS）中能够保持一定程度的稳定.摩擦学考察结果显示PDA-ALD-NP具有较好的摩擦学性能.此外,采用MTT法考察了DOPA和两种纳米粒的生物相容性.

英文摘要：

Taking advantage of the properties of dopamine （DOAP） forming polydopamine （PDA） in aerobic alkaline solution, and using alendronate sodium as model drug, the author prepared blank polydopamine nanoparticles（PDA- NP）and alendronate sodium-loaded polydopamine nanopartieles（PDA-ALD-NP）. Using characterization methods of DLS,TEM,UV, and so on, the author preliminarily studied the two kinds of nanoparticles size and Zeta potential, external morphology, drug loading capacity, cumulative release, stability, tribology performance and cytotoxic effect.The results shows that the average sizes are less than 102 nm and have narrow size distribution, and the zeta potentials are around --25 mV. The author observed the morphology of the two nanoparticles making use of scanning electron microscope （SEM）. The results show that both PDA-NP and PDA-ALD-NP are smooth and round. The drug loading of PDA-ALD-NP detected by UV-Vis spectrophotometry is 5.3%± 1.2%. The release in vitro displays that the PDA-ALD-NP can significantly slow down the release of ALD. In addition, the author studied the stability of PDA-ALD-NP in vitro and found that PDA-ALD-NP is able to maintain a certain degree of stability in aqueous solution and fetal bovine serum （FBS）.Tribological investigation shows that PDA-ALD-NP has better tribological performance. In addition, MTT method was used to inspect the biocompatibility of DOPA and two types of nanoparticles.