尿酸是机体嘌呤代谢的终末产物,尿酸水平升高显著增加痛风、心血管疾病、2型糖尿病等疾病发病风险.近年来的研究表明,高尿酸血症与非酒精性脂肪性肝病(NAFLD)关系密切.本文结合笔者所在课题组近年来研究结果,就高尿酸血症与NAFLD相互关系及其机制研究进展作一概述.
Uric acid is the end-product of purine metabolism.It has been widely accepted that the increase in the level of uric acid significantly raises the risks of gout,cardiovascular disease,and type 2 diabetes.The studies in recent years have shown that hyperuricemia is closed related to nonalcoholic fatty liver disease (NAFLD).This review summarizes the research advances in the association between hyperuricemia and NAFLD and related mechanisms based on the author's recent research findings.