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中文摘要：
4-（4-羟基苯基）乙基儿茶酚是一种新型幽门螺旋杆菌尿素酶抑制剂，运用酶动力学研究方法，对它的抑制机理、抑制类型进行探讨．实验结果表明，4-（4-羟基苯基）乙基儿茶酚是尿素酶的竞争性抑制剂，抑制常数K：为1．48／μmol／L，为其在抗胃炎、胃溃疡方面的应用以及进一步的结构优化奠定了理论基础．
英文摘要：
4-（4-Hydroxyphenethyl） benzene-l, 2-diol is a new inhibitor against Helicobacter Pylori ure- ase. The inhibition mechanism was herein investigated through enzyme kinetics methods,and the results revealed that 4-（4-hydroxyphenethyl）benzene-1,2-diol was competitive inhibitor of urease with a Ki val- ue of 1.48 t~mol/L. The chemical stabilitiy and the competitive mechanism of 4-（4-hydroxyphenethyl）- benzene-1,2-diol strongly suggested that it could be used as a lead compound for rational drug design to find active compound and as a potential urease inhibitor for treatment of gastritis and peptic ulcer.
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