中文摘要：

背景：由 CD4 (+) CD25 (+) 的活跃抑制规章的 T 淋巴细胞戏在对的 T 房间回答的下面规定的一个重要角色外国并且自我抗原。这研究被进行分析是否 CD4 (+) CD25 (+) 规章的 T 房间在有结节的胸膜渗漏通常存在并且工作。方法：在从有结核性胸膜炎的病人的胸膜渗漏和外部血和从健康控制题目的外部血的 CD4 (+) CD25 (+) T 房间的百分比被流动血细胞计数决定。叉头抄写因素 Foxp3 的表示也被检验。从胸膜渗漏和血的 CD4 (+) CD25 (+) 和 CD4 (+) CD25 (-) T 房间被孤立，并且是有教养的在 CD4 (+) CD25 (-) T 房间在试管内的增长反应上观察 CD4 (+) CD25 (+) T 房间的效果。结果：与从有结核性胸膜炎和正常题目的两个病人的外部血相比有在有结节的胸膜渗漏的 CD4 (+) CD25 (+) T 房间的增加的数字，并且这些房间表明了 Foxp3 的组成的高级表情。而且， CD4 (+) CD25 (+) T 房间调停了 CD4 (+) CD25 (-) T 房间的增长反应的有势力抑制。结论：在有结节的胸膜渗漏的增加的 CD4 (+) CD25 (+) T 房间表示 Foxp3 抄写因素的高水平，当 potently 压制 CD4 (+) CD25 (-) T 房间的增长时。

英文摘要：

Background Active suppression by CD4^＋CD25^＋ regulatory T lymphocytes plays an important role in the down-regulation of T cell responses to foreign and self-antigens. This study was conducted to analyze whether the CD4^＋CD25^＋ regulatory T cells exist and function normally in tuberculous pleural effusion. Methods The percentages of CD4^＋CD25^＋ T cells in pleural effusion and peripheral blood from patients with tuberculous pleurisy and peripheral blood from healthy control subjects were determined by flow cytometry. The expression of forkhead transcription factor Foxp3 was also examined. CD4^＋CD25^＋ and CD4^＋CD25^-T cells from pleural effusion and blood were isolated, and were cultured to observe the effects of CD4^＋CD25^＋ T cells on proliferation response of CD4^＋CD25^- T cells in vitro. Results There were increased numbers of CD4^＋CD25^＋ T cells in tuberculous pleural effusion compared with peripheral blood from both patients with tuberculous pleurisy and normal subjects, and these cells demonstrated a constitutive high-level expression of Foxp3. Moreover, CD4^＋CD25^＋ T cells mediated potent inhibition of proliferation response of CD4^＋CD25^- T cells. Conclusion The increased CD4^＋CD25^＋ T cells in tuberculous pleural effusion express a high level of Foxp3 transcription factor, while potently suppressing the proliferation of CD4^＋CD25^- T cells.