中文摘要：

目的：研究Erzin蛋白在宫颈上皮癌变过程中的表达特点及其意义。方法：利用免疫组化SP法检测Ezrin在23例宫颈正常上皮,19例宫颈上皮内瘤变（CIN）Ⅰ～Ⅱ级,13例CINⅢ和58例宫颈鳞癌组织中的表达。结果：在宫颈正常上皮、CINⅠ～Ⅲ、宫颈鳞癌组织中Erzin表达逐渐增强。Erzin蛋白在CINⅢ组织及宫颈鳞癌组织中的表达明显高于正常宫颈上皮（P〈0.05）。宫颈鳞癌伴淋巴结转移者Erzin蛋白表达明显高于未转移者（P〈0.05）,Erzin蛋白表达与患者年龄、肿瘤大小、肿瘤临床分期和分级等因素无关。结论：Erzin蛋白的过表达在宫颈癌的发生及发展中发挥一定的作用,Erzin蛋白的检测可作为预测宫颈癌预后的指标之一。

英文摘要：

Objective：To investigate the expression of Erzin in cervical epithelium with malignant transformation. Methods：Erzin protein expression in normal cervical epithelium（n=23）, CINⅠ～Ⅱ（n=19）,CINⅢ（n=13） and cervical squamous epithelia carcinoma（n=58） were investigated with immunohistochemical staining, followed by light microscopic examination. Results：The expression of Erzin CINⅢ cervical squamous epithelia carcinoma were significantly higher than those in normal cervical epithelium（P0.05）.It was also noted that the expression of Erzin were correlated well with lymph node metastasis（P0.05）, but not correlated with clinical staging, tumor sizes and age of patients. Conclusion：The overexpression of Erzin plays the important role in carcinogenesis and progression of cervical carcinoma. Erzin is possible to be used as a predictor for prognosis of cervical cancer.