中文摘要：

目的：观察复方蜥蜴散不同微粒组合剂对急性酒精性胃黏膜损伤模型大鼠血清EGF、GAS水平的影响，探讨其治疗修复胃黏膜损伤的作用机制。方法：将60只健康雄性sD大鼠随机分为正常对照组、模型对照组、丽珠得乐治疗组、复方蜥蜴散80目治疗组、复方蜥蜴散100目治疗组、复方蜥蜴散（80目＋100目）治疗组。正常对照组除外，余组均采用95％乙醇诱导急性胃黏膜损伤模型，治疗组大鼠给予复方蜥蜴散不同微粒剂及丽珠得乐治疗5天，采用酶联免疫法（ELISA）检测大鼠血清EGF、GAS的水平，光镜观察胃黏膜病理组织学变化。结果：各治疗组大鼠EGF水平明显高于模型组（P〈0．01），GAS水平明显低于模型组（P〈0．01）。复方蜥蜴散（80目＋100目）组大鼠EGF水平高于丽珠得乐组（P〈0．05）；复方蜥蜴散（80目＋100目）组大鼠GAS水平低于丽珠得乐组（P〈0．05）。且胃黏膜病理组织学损伤有明显改善。结论：复方蜥蜴散不同微粒组合剂对急性胃黏膜损伤有治疗作用，能提高血清EGF含量，降低血清GAS含量，可能通过改善胃黏膜屏障功能，抑制胃酸分泌等作用，达到对胃黏膜的治疗修复作用。

英文摘要：

Objective：To observe the therapeutic effect of different combinations of Compound Lizards Powder （DCCLP） in gastric mucosal injury of rat which induced by ethanol, and explore the mechanism of the therapeutic action of DCCLP on acute gastric mucosal lesions. Methods ：60 SD healthy male rats were randomly divided into normal control group, model control group, Franc Side1 treated group, Compound Powder Lizards 80 mesh treated group, Compound Powder Lizards 100 mesh treated group, DCLP（ 80 mesh ＋ 100 mesh） treated group. Except normal control group rats, others were made to model of acute gastric mucosal injury with 95% Ethanol. When the model was established successfully,treated group rats were given different dose medicines for 5 days. And then, all the rats were sacrificed. Their blood serum was collected to detect EGF and GAS by ELISA and the histologi- cal mucosa changes detected by HE. Results ： Compared with model group, the level of serum EGF in the rats of the all treatment groups was significantly higher（ P 〈 0.01 ） , and the level of serum GAS in the rats of the all treatment groups was significantly lower（ P 〈 0.01 ）. The level of serum EGF in the rats of the DCLP treated group was higher than that of Franc Sidel treated group （ P 〈 0.05 ）, and the level of serum GAS in the rats of the DCLP treated group was lower than that of Franc Sidel treated group （ P 〈 0.05 ）. The pathologic changes of injured gastric mucosa were significantly improved. Conclusion. Different combination of Com- pound Lizards Powder has the function of repair injured gastric mucosal by lowering the serum gastrin and improving the serum epidemic growth factor and reducing mucosal aggressive factors and reinforcing the prevention of gastric mucosa.