中文摘要：

目的观察阿扑吗啡（AP0）和亚氨基二丙腈（IDPN）诱导的抽动障碍（TD）模型大鼠的刻板运动和头动次数，挑选可以全面体现TD特征性行为变化的造模方法。方法SD大鼠30只按随机数字表法分为正常组、AP0组、IDPN组，每组10只。AP0组大鼠给予APO2mg／kg腹腔注射，IDPN组大鼠给予IDPN150mg以（g腹腔注射，正常组给予生理盐水腹腔注射，给药体积均为1mL／100g、每天1次、连用7d，注射结束5min后记录各组大鼠5～10min、15～20min、25～30min、35-40min、45～50min、55～60min时间段的刻板行为评分和5min内大鼠头部抽动次数。结果IDPN组和APO组的大鼠头动次数明显比正常组多，IDPN组大鼠的头动次数多于AP0组．差异均有统计学意义（P〈0．05）；APO组大鼠在5～10min、15-20min、25～30min、35-40min时间段刻板行为评分高于正常组．IDPN组大鼠各个时段的刻板行为学评分均高于正常组．IDPN组大鼠在45～50min和55～60min时间段刻板行为评分高于APO组，差异均有统计学意义（P〈0．05）。结论IDPN诱导的TD模型能比较全面的再现TD的特征性行为变化，是较理想的动物模型。

英文摘要：

Objective To observe the stereotypy and the movement of head in rat models of tic disorder （TD） induced by apomorphine （APO） or iminodipropionitrile （IDPN）, and select the best method for making rat models fully reflecting the characteristic behavior change. Methods A total of 30 male SD rats weighing 100-110 g were randomly divided into APO inducement group, IDPN inducement group and control group （n=10）. The rats in the APO inducement group were intraperitoneally injected 2 mg/kg APO, and those in the 1DPN inducement group were intraperitoneally injected 150 mg/kg IDPN; equal volume of saline was injected into the rats of the control group; treatments were given daily for a consecutive 7 d at a dosing volume of 1 mL/100 g. The stereotypy scale scores were observed and recorded at 5-10 min, 15-20 rain, 25-30 min, 35-40 min, 45-50 min and 55-60 min after the treatment. Movement of head was noted within 5 min of sucess model making. Results The head move number of the rats in the APO and IDPN inducement groups was significantly larger than that in the control group （P〈0.05）; the head move number of the rats in the IDPN inducement group was obviously larger than that in the APO inducement group （P〈0.05）. The stereotyped behavior scores of rats in the APO inducement group were significantly higher than those in the control group at 5-10 min, 15-20 min, 25-30 min, and 35-40 min after treatment （P〈0.05）; those of rats in the IDPN inducement group were higher than those in the control group at every time interval （P〈0.05）; those in the IDPN inducement group were higher than those in the APO inducement group at 45-50 min and 55-60 min after tre atment （P〈0.05）. Conclusion The behavioral changes of TD models induced by IDPN are more obvious than those of models induced by APO; TD model induced by IDPN is an ideal animal model for observing tic disorder.