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针刺对胃运动调节效应的机制浅析
  • 期刊名称:中华中医药杂志( 原中国医药学报)
  • 时间:0
  • 页码:103-107
  • 语言:中文
  • 分类:R589.2[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:南京中医药大学针药结合省部共建教育部重点实验室,南京210029
  • 相关基金:国家自然科学基金项目(No.30873307)~~
  • 相关项目:针刺不同穴位影响肥胖大鼠下丘脑GS活动及AMPK表达的研究
中文摘要:

目的:观察温针联合耳针对痰湿内阻型肥胖并发高脂血症患者的疗效及其作用机制。方法:本研究共纳入162例,其中52例为正常组,110例痰湿内阻型肥胖并发高脂血症患者随机分为治疗组(温针联合耳针埋压)和对照组(温针灸),每组55例。观察两组患者治疗前后患者的体质量、肥胖度(A)、体脂百分率(F%)、体质指数(BMI)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)、高密度脂蛋白胆固醇(HDL-c)、空腹血糖(FPG)、空腹胰岛素(FINS)、空腹瘦素(FLP)、胰岛素抵抗指数(Homa-IR)、胰岛素敏感指数(ISI)、胰岛素分泌指数(Homa-β)水平及植物神经功能指数(Y)的变化和疗效。结果:治疗组的总有效率为96.4%,对照组为85.5%,组间具有显著性差异(P〈0.01)。两组患者治疗前TC、TG、LDL-c、FPG、FINS、Homa-IR、FLP水平均显著高于正常组(P〈0.01),而HDL-c、ISI、Homa-β、Y值却显著低于正常组(P〈0.01)。两组患者治疗后体质量、肥胖度(A)、体脂百分率(F%)、体质指数(BMI)肥胖指标均有显著降低(P〈0.01);两组治疗前后差值比较中除F%治疗前后差值其他肥胖指标差异均有统计学意义(P〈0.05)。两组治疗后TC、TG、LDL-C血脂指标水平均显著降低(P〈0.01),HDL-C各血脂指标水平回升明显(P〈0.01)。治疗组与对照组治疗后比较,各项血脂指标水平的调节优于对照组(P〈0.01);两组患者治疗前后TC、TG、LDL-C的差值比较差异有统计学意义(P〈0.01,P〈0.05)。两组治疗后FPG、FINS、FLP、Homa-IR三项指标与治疗前比较差异有统计学意义(P〈0.01),治疗组治疗后FPG、FINS、FLP、Homa-IR指标较对照组治疗后降低更明显(P〈0.01)。两组患者治疗后自主神经功能指数Y值均出现向正常组回归的趋势,治疗组疗效更显著。结论:温针联合耳针埋压?

英文摘要:

Objective: To observe the effect of a combination of warming needle moxibustion and auricular needle on the treatment of patients with obesity with syndrome of accumulation of phlegm-wetness in the body complicated with hyperlipidemia, and to explore its underlying mechanism. Methods: The study included 162 cases, including 52 cases of normal group and 110 cases of patients with obesity with syndrome of accumulation of phlegm-wetness in the body complicated with hyperlipidemia that were randomly divided into treatment group(a combination of warming needle moxibustion and auricular needle) and control group(warming needle moxibustion), 55 cases in each group. Before and after treatment, the changes in the body weight, degree of obesity(A), body fat percentage(F%), body mass index(BMI), triglycerides(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-c), high density lipoprotein cholesterol(HDL-c), fasting blood glucose(FPG), fasting insulin(FINS), fasting leptin(FLP), insulin resistance index(Homa-IR), insulin sensitivity index(ISI), insulin secretion index(Homa-β) and autonomic nerve function index(Y) were used to evaluate the effect of treatment. Results: The comparison of curative effect in the treatment group and the control group showed that curative effect of the treatment group and the control group were respectively 96.4% and 85.5%, with being statistically significant(P〈0.01). Compared with the normal group, the levels of TC, TG, LDL-c, FPG, FINS, Homa-IR and FLP in the two treatment groups before the treatment were increased(P〈0.01), while the levels of HDL-c, ISI, Homa-β and Y in the two treatment groups were decreased(P〈0.01). Compare with before the treatment, the body weight, A, F%, and BMI in the treatment groups were decreased after the treatment(P〈0.01). Particularly, there were statistical differences in all of obesity indexes except for F% between before and after treatment(P〈0.05

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