中文摘要：

肺动脉高压是一种常见的临床综合征。肺动脉平滑肌细胞的过度增殖是构成肺血管重塑的主要病理基础，而肺血管重塑是导致肺动脉高压发生的关键病理变化。本文总结了促进肺动脉平滑肌细胞增殖的分子信号通路的研究进展，并介绍了目前抑制肺动脉平滑肌细胞增殖靶向治疗的现状及研究进展。

英文摘要：

Pulmonary artery hypertension （PAH） is a common clinical syndrome. The over-proliferation of pulmonary artcrial smooth muscle cells （PASMCs） is a hallmark of pulmonary vascular remodeling which is a critical and fundamental pathogenesis in the development of a variety of pulmonary artery hypertension. Here, wc review the advances in studies on signaling transduction pathways mediating the proliferation of PASMCs and also introduce the existing approaches in inhibiting their proliferation and relevant research advances.